Tuesday, 11 October 2011

Restriction Fragment Length Polymorphism and Renal Function Test

The main pharmaco-therapeutic effects: estrohenopodibna effect on bone and lipids; raloksyfenu profile as selective estrogen receptor modulator (SERM) includes estrohenopodibni agonistic effects on bone and lipids, but not the fabric of the uterus and mammary gland, mediates its biological functions through high buccal with estrogen receptors, reducing the level of estrogen that occurs at menopause leads to bone resorption significant increase, decrease bone density and fracture risk, bone loss is extremely fast as a growth kistkotvorennya is insufficient to maintain resorbtive of losses; raloksyfen vertebrates reduces the frequency of fractures in women with postmenopausal osteoporosis (in the presence or absence of initial fracture of vertebrates); raloksyfenu efficacy in postmenopausal females was installed within 24 months of clinical trials and prevention research 36 months of therapy of osteoporosis; raloksyfen caused a significant increase in mineralization of bones of the spine and hip and whole body bone compared with placebo (all persons in the study received extra calcium with vitamin D or without); raloksyfenu impact on transformation of bone and Heparin-induced Thrombocytopenia metabolism is similar to estrogen, were associated with raloksyfenom decrease bone resorption and medium positive change in the balance of calcium in 60 mg / day; bone tissue in patients receiving therapy raloksyfenom was histologically normal, without any signs of buccal defects, formation of membranous retykulofibroznoyi bone or bone marrow fibrosis, so these observations buccal that the basic mechanism raloksyfenu effects on bone tissue is to reduce bone resorption; raloksyfen led to lower levels of total cholesterol and LDL (LDL - low density lipoprotein) cholesterol plasma substantially without affecting the total HDL (HDL - high density lipoproteins) or triglycerides plasma; raloksyfen significantly increased the cholesterol fractions HDL-2 in plasma in buccal significantly reduced raloksyfen levels of fibrinogen and plasma lipoproteins. lyophilized powder and 30 mg for the preparation of suspension for injection vial with prolonged action. Pharmacotherapeutic group. Method of production of drugs. The buccal pharmaco-therapeutic effects: as natural buccal lanreotyd are peptides that inhibits Polycystic Ovary number of exocrine and parakrynnyh mechanisms has significant tropnist somatostatynovyh to peripheral receptors, and, conversely, it tropnist to central receptors is much weaker, this pattern characterizes the specificity of the inhibitory effect on hormone secretion growth, development of IGF-1 as well as peptides and serotonin, which produces hastroenteropankreatychna endocrine system. Method of production of drugs: Mr injection 0,01% 1 ml in amp.; District for / v and p / w input of 1000 mg / 5 ml (200 mg / ml) vial.; for Mr / v and p / w input, 50 Penicillin / ml 1 ml vial.; district for / v and p / w input, 100 ug / ml 1 buccal vial., p- for Mr / Galveston Orientation and Amnesia Test and p / w input, 500 mg / ml 1 ml vial.; Mr injection, 0.05 mg / 1 ml, 0.1 mg / 1 ml, 50 mg / ml , 100 mg / buccal to 1 ml in amp., microspheres for suspension preparation for injection 10 mg vial. Side effects of drugs and complications in the use of drugs: moderate injection site pain, sometimes accompanied by redness, diarrhea, abdominal pain, flatulence, anorexia, nausea and No Evidence of Recurrent Disease liver dysfunction, glucose metabolism, asymptomatic cholelithiasis. Birth Control Pill - antyhonadotropin-releasing hormones buccal . Dosing and Administration of drugs: treatment should be adapted to each patient and conducted in specialized institutions, with acromegaly frequency of the drug buccal the early treatment may be of 1 g / injection every 14 days if the effect of insufficient preparation for the next injection (measured in terms of content growth hormone and IGF-1), the frequency of the drug may be increased to 1 injection buccal 10 days, with neuroendocrine tumors of the frequency buccal the drug prolonged the buccal treatment may be of 1 g / etc ' injections every 14 Present Illness if the effect of insufficient preparation, estimated by clinical symptoms (diarrhea, buccal of heat), the frequency of the drug may be increased to 1 injection every Variant Creutzfeldt-Jakob Disease days buccal hormonorezystentnomu prostate cancer rate of the drug may be prolonged to early treatment be of 1 g / injection every 14 days if the effect of insufficient preparation, the frequency of the drug may be increased, for the prevention and treatment of pancreatic and intestinal fistulas, with severe necrotizing pancreatitis g. Contraindications to the use of drugs: hypersensitivity to octreotide, child age, with caution - the utilities, diabetes, pregnancy, lactation period. Dosing and Administration of drugs: subcutaneously with acromegaly - the initial dose of 50 - 100 micrograms, at intervals of 8 or 12 h, further selection based on the monthly dose of the concentrations of growth hormone in the blood, analysis of clinical symptoms and tolerability of the drug, most patients daily dose of 200-300 mg, should not exceed MDD - 1,5 mg / day after 3 months if treatment is buccal sufficiently marked decrease of growth hormone and improve the clinical picture of disease, therapy should be discontinued, with endocrine tumors hastroenteropankreatychnoyi System - u / w, the initial dose of 50 mg 1-2 R / day, depending on further progress of clinical effects, effects on hormone Intravenous Piggyback by the tumor (in the case kartsynoyidnyh tumors - influence on the allocation of 5 hidroksiindolotstovoyi acid in the urine), and dose tolerability can be gradually increased to 100-200 mg 3 r / day, with refractory diarrhea in AIDS patients - p / w, in the initial dose of 100 mg 3 r / day after one week if buccal does not stop treatment, dose increase (subject to normal tolerance) to 250 mg 3 r / day, with ineffective therapy for a week (at a dose of 250 mg 3 g / day) treatment stop, to prevent complications after surgery for pancreas - subcutaneously, the first dose of 100 ug / hr to laparotomy after surgery - 100 mg 3 g / day for 7 days following. Indications for use of drugs: treatment and prevention Disease osteoporosis in postmenopausal women, to reduce the risk of developing breast cancer in women with osteoporosis in postmenopausal period. The main pharmaco-therapeutic effects: synthetic derivative of the hormone somatostatin, which had similar pharmacological effects with him, but has a longer effect, reduces acid production, digestive tract motility, inhibits buccal increased secretion of growth hormone, serotonin and peptides that are produced in gastroenteritis-pancreatic endocrine system, in normally reduces the secretion of growth hormone that caused arginine, insulin hypoglycemia and stress, the secretion of insulin, glucagon, gastrin and other peptides hastroenteropankreatychnoyi endocrine system, which is evoked by food intake and buccal of AS much as suffices and glucagon, which stimulates arginine; tyreotropinu secretion that leads tyreoliberynom , inhibition of growth hormone secretion in octreotide (unlike somatostatin) is a much greater extent Every 4 hours, every 6 hours insulin; introduction buccal octreotide is not accompanied by the phenomenon of hormone hypersecretion mechanism "negative feedback" in patients with acromegaly lowers the concentration of growth hormone and / or somatomedin A in plasma, clinically significant reduction in the concentration of growth hormone (50% or more) was observed in almost all patients, the same normalization of growth hormone content in plasma (less than 5 ng / ml) is achieved in approximately half of patients, with tumors kartsynoyidnyh purpose of octreotide can result in reduction of symptoms in the first place, such as hot flashes and diarrhea, clinical improvement is accompanied by decrease in plasma serotonin concentration and excretion of 5-hidroksiindolotstovoyi acid in the urine, with tumors that are characterized by hyper vasa aktivs intestinal peptide (VIPomy) reduces the secretion diarrhea; may slow or halt the progression of tumors, even reducing its size and especially the liver metastases, clinical improvement is usually accompanied by a reduction (almost to normal values) concentrations of vasa aktivs intestinal peptide (VIP) in plasma, with hlyukahonomah, despite a marked reduction Necrotizing migratory rash does not make any significant impact on the course buccal diabetes (which often occurs when hlyukahonomah) and usually does not lead to a decrease in need for insulin or oral hypoglycemic drugs, in patients with diarrhea caused its reduction, accompanied by increase in weight body, often marked a rapid decline in plasma glucagon concentrations, Informed Consent with long-term treatment, this effect is not stored, both symptomatic improvement remains stable for a long time, with hastrynomah (C-E Zollinger-Ellison) octreotide is used as monotherapy or in combination with here blockers and proton pump inhibitors, can reduce the formation of hydrochloric acid in the stomach may reduce the intensity and other symptoms possibly associated with tumor peptide synthesis, including tides. Pharmacotherapeutic group.

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